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GLP-1 and SGLT-2 have the highest level of clinical evidence for use in this population, per the American Diabetes Association (ADA) guidelines.[3] Both GLP-1 and SGTL-2 products, such as Jardiance, have the ability to improve blood glucose control (hemoglobin A1c reduction), potentiate weight loss and provide a cardiovascular protective effect
Observational studies suggest that GLP-1RA therapy may be associated with changes in musculoskeletal parameters under conditions of rapid weight loss [34, 40]
Int J Food Nutr Sci
doi: 10.1093/molbev/msad177 94 Gonzlez-RodrguezT.Cisneros-HernndezI.BayonaJ
The study "Liraglutide versus placebo as an adjunct to glucose-lowering therapy in patients with type 2 diabetes and moderate renal failure" (LIRA-RENAL) did not demonstrate a benefit of liraglutide in lowering eGFR, although the duration of the study (26 weeks) may have been insufficient to show an effect
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